prasugrel metabolite (BOC Sciences)
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Structured Review
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prasugrel metabolite
Prasugrel Metabolite, supplied by BOC Sciences, used in various techniques. Bioz Stars score: 93/100, based on 6 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/prasugrel metabolite/product/BOC Sciences
Average 93 stars, based on 6 article reviews
Prasugrel Metabolite, supplied by BOC Sciences, used in various techniques. Bioz Stars score: 93/100, based on 6 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/prasugrel metabolite/product/BOC Sciences
Average 93 stars, based on 6 article reviews
prasugrel metabolite - by Bioz Stars,
2026-02
93/100 stars
Images
1) Product Images from "Interactions of fentanyl with blood platelets and plasma proteins: platelet sensitivity to prasugrel metabolite is not affected by fentanyl under in vitro conditions"
Article Title: Interactions of fentanyl with blood platelets and plasma proteins: platelet sensitivity to prasugrel metabolite is not affected by fentanyl under in vitro conditions
Journal: Pharmacological Reports
doi: 10.1007/s43440-023-00447-7
Figure Legend Snippet: Effect of fentanyl on platelet aggregation in whole blood. The influence of 2 or 2000 ng/ml fentanyl on whole blood platelet aggregation was measured in non-stimulated cells ( A ), cells stimulated with 2 µM ADP in combination with fentanyl ( B , C ), and cells stimulated with 5 µM ADP after 15-min preincubation with prasugrel metabolite and fentanyl ( D , E ). Data with normal distribution ( A , C ‒ E ) are expressed as mean ± SD, and those with non-normal distribution ( B ) are given as median with interquartile range, n = 6. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001 vs. control
Techniques Used: Control
Figure Legend Snippet: The effect of fentanyl on ADP-induced platelet aggregation in PRP in the absence and presence of prasugrel metabolite
Techniques Used: Control, Incubation
Figure Legend Snippet: Representative curves of ADP-induced platelet aggregation measured by LTA. The effect of fentanyl on agonist-induced platelet function was measured in PRP, in the absence or presence of 1.3 µM prasugrel metabolite (PM). The example data show platelet response to fentanyl added to PRP with subthreshold concentration of ADP ( A ) or preincubated with PM before stimulation of PRP with 5 µM ADP
Techniques Used: Concentration Assay
Figure Legend Snippet: Effect of fentanyl on platelet activation. The influence of 2 or 2000 ng/ml fentanyl on platelet function was measured in blood, PRP or suspensions of isolated platelets in the following models: non-stimulated cells ( A ), cells stimulated with 2 µM ADP in combination with fentanyl ( B ), cells stimulated with 2 µM ADP after 15-min preincubation with fentanyl ( C ), and cells stimulated with 10 µM ADP after 15-min preincubation with prasugrel metabolite and fentanyl ( D ). Data with normal distribution ( A , B : PRP/platelets, C / D : blood/platelets, D : blood/PRP) are expressed as mean ± SD; otherwise data are presented as median with interquartile range, n = 6‒7. Before statistical analysis, data showing departure from normal distribution were log transformed for normalization. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001 vs. the appropriate controls: vehicle ( A ) or ADP ( B ‒ D )
Techniques Used: Activation Assay, Isolation, Transformation Assay
Figure Legend Snippet: Summary of kinetic constants and binding affinities for the interactions of fentanyl and prasugrel metabolite with human plasma proteins assayed by SPR
Techniques Used: Binding Assay, Clinical Proteomics
Figure Legend Snippet: Representative SPR sensograms showing the interactions of fentanyl or prasugrel metabolite with HSA, α 1 -AGP, ApoA-1, or ApoB-100. The proteins were immobilized to a dextran-coated gold surface. Injection of analyte (10, 20, 40 80 μM fentanyl or 2, 5, 10 μM prasugrel metabolite) produced a signal change that was directly proportional to the mass of bound drug molecules, expressed in resonance units (RU). Further details are given in
Techniques Used: Injection, Produced